| state | senator (party) | service began | term ends |
|---|---|---|---|
| 1Martha McSally was appointed in December 2018 and took office the following month to fill the vacancy caused by the resignation of Jon Kyl, who had been appointed in September 2018 to fill the vacancy caused by the death of John McCain. Mark Kelly won a special election in November 2020 and took office in December. | |||
| 2Dianne Feinstein was elected in November 1992 to complete the term of Pete Wilson, who resigned in 1991 to become California's governor. | |||
| 3Alex Padilla was appointed in December 2020 and took office in January 2021 to complete the term of Kamala Harris, who resigned to become vice president. | |||
| 4Michael F. Bennet was appointed in January 2009 to complete the term of Ken Salazar, who resigned to become secretary of the interior. | |||
| 5Ted Kaufman was appointed in January 2009 to replace Joe Biden, who resigned to become vice president. In 2010 Christopher A. Coons won a special election to complete the term. | |||
| 6Kelly Loeffler was appointed in December 2019 and took office in January 2020 to fill the vacancy caused by the resignation of Johnny Isakson. Raphael G. Warnock won a special election in November 2020 and took office in January 2021. | |||
| 7Brian Schatz was appointed in December 2012 to fill the vacancy caused by the death of Daniel Inouye. | |||
| 8William Cowan was appointed in January 2013 and took office in February to replace John Kerry, who resigned to become secretary of state. In July 2013 Ed Markey won a special election to complete the term. | |||
| 9Tina Smith was appointed in December 2017 and took office in January 2018 to fill the vacancy caused by the resignation of Al Franken. | |||
| 10Roger Wicker was appointed in December 2007 to fill the vacancy caused by the resignation of Trent Lott. | |||
| 11Cindy Hyde-Smith was appointed in March 2018 and took office in April to fill the vacancy caused by the resignation of Thad Cochran. | |||
| 12Robert Menendez was appointed in January 2006 to fill the vacancy caused by the resignation of Jon S. Corzine. | |||
| 13Jeff Chiesa was appointed in June 2013 to fill the vacancy caused by the death of Frank R. Lautenberg. In October 2013 Cory A. Booker won a special election to complete the term. | |||
| 14Kirsten Gillibrand was appointed in January 2009 to replace Hillary Rodham Clinton, who resigned to become secretary of state. | |||
| 15James M. Inhofe was elected in November 1994 to complete the term of David Boren, who resigned to become president of the University of Oklahoma. | |||
| 16Ron Wyden was elected in January 1996 to complete the term of Bob Packwood, who resigned in 1995. | |||
| 17Tim Scott was appointed in December 2012 and took office in January 2013 to fill the vacancy caused by the retirement of Jim DeMint. | |||
| 18Joseph Manchin III won a special election in 2010 to fill the vacancy caused by the death of Robert C. Byrd. | |||
| 19John Barrasso was appointed in June 2007 to fill the vacancy caused by the death of Craig Thomas. | |||
| Alabama | Richard C. Shelby (R) | 1987 | 2023 |
| Tommy Tuberville (R) | 2021 | 2027 | |
| Alaska | Lisa Murkowski (R) | 2002 | 2023 |
| Dan Sullivan (R) | 2015 | 2027 | |
| Arizona | Kyrsten Sinema (D) | 2019 | 2025 |
| Mark Kelly (D) | 20201 | 2023 | |
| Arkansas | John Boozman (R) | 2011 | 2023 |
| Tom Cotton (R) | 2015 | 2027 | |
| California | Dianne Feinstein (D) | 19922 | 2025 |
| Alex Padilla (D) | 20213 | 2023 | |
| Colorado | Michael F. Bennet (D) | 20094 | 2023 |
| John W. Hickenlooper (D) | 2021 | 2027 | |
| Connecticut | Richard Blumenthal (D) | 2011 | 2023 |
| Christopher Murphy (D) | 2013 | 2025 | |
| Delaware | Thomas R. Carper (D) | 2001 | 2025 |
| Christopher A. Coons (D) | 20105 | 2027 | |
| Florida | Marco Rubio (R) | 2011 | 2023 |
| Rick Scott (R) | 2019 | 2025 | |
| Georgia | Jon Ossoff (D) | 2021 | 2027 |
| Raphael G. Warnock (D) | 20216 | 2023 | |
| Hawaii | Mazie K. Hirono (D) | 2013 | 2025 |
| Brian Schatz (D) | 20127 | 2023 | |
| Idaho | Mike Crapo (R) | 1999 | 2023 |
| James E. Risch (R) | 2009 | 2027 | |
| Illinois | Dick Durbin (D) | 1997 | 2027 |
| Tammy Duckworth (D) | 2017 | 2023 | |
| Indiana | Todd Young (R) | 2017 | 2023 |
| Mike Braun (R) | 2019 | 2025 | |
| Iowa | Chuck Grassley (R) | 1981 | 2023 |
| Joni Ernst (R) | 2015 | 2027 | |
| Kansas | Jerry Moran (R) | 2011 | 2023 |
| Roger Marshall (R) | 2021 | 2027 | |
| Kentucky | Mitch McConnell (R) | 1985 | 2027 |
| Rand Paul (R) | 2011 | 2023 | |
| Louisiana | Bill Cassidy (R) | 2015 | 2027 |
| John Kennedy (R) | 2017 | 2023 | |
| Maine | Susan Collins (R) | 1997 | 2027 |
| Angus King (I) | 2013 | 2025 | |
| Maryland | Benjamin L. Cardin (D) | 2007 | 2025 |
| Chris Van Hollen (D) | 2017 | 2023 | |
| Massachusetts | Elizabeth Warren (D) | 2013 | 2025 |
| Edward J. Markey (D) | 20138 | 2027 | |
| Michigan | Debbie Stabenow (D) | 2001 | 2025 |
| Gary Peters (D) | 2015 | 2027 | |
| Minnesota | Amy Klobuchar (D) | 2007 | 2025 |
| Tina Smith (D) | 20189 | 2027 | |
| Mississippi | Roger F. Wicker (R) | 200710 | 2025 |
| Cindy Hyde-Smith (R) | 201811 | 2027 | |
| Missouri | Roy Blunt (R) | 2011 | 2023 |
| Josh Hawley (R) | 2019 | 2025 | |
| Montana | Jon Tester (D) | 2007 | 2025 |
| Steve Daines (R) | 2015 | 2027 | |
| Nebraska | Deb Fischer (R) | 2013 | 2025 |
| Ben Sasse (R) | 2015 | 2027 | |
| Nevada | Catherine Cortez Masto (D) | 2017 | 2023 |
| Jacky Rosen (D) | 2019 | 2025 | |
| New Hampshire | Jeanne Shaheen (D) | 2009 | 2027 |
| Margaret Wood Hassan (D) | 2017 | 2023 | |
| New Jersey | Robert Menendez (D) | 200612 | 2025 |
| Cory A. Booker (D) | 201313 | 2027 | |
| New Mexico | Martin Heinrich (D) | 2013 | 2025 |
| Ben Ray Luján (D) | 2021 | 2027 | |
| New York | Charles E. Schumer (D) | 1999 | 2023 |
| Kirsten E. Gillibrand (D) | 200914 | 2025 | |
| North Carolina | Richard Burr (R) | 2005 | 2023 |
| Thom Tillis (R) | 2015 | 2027 | |
| North Dakota | John Hoeven (R) | 2011 | 2023 |
| Kevin Cramer (R) | 2019 | 2025 | |
| Ohio | Sherrod Brown (D) | 2007 | 2025 |
| Rob Portman (R) | 2011 | 2023 | |
| Oklahoma | James M. Inhofe (R) | 199415 | 2027 |
| James Lankford (R) | 2015 | 2027 | |
| Oregon | Ron Wyden (D) | 199616 | 2023 |
| Jeff Merkley (D) | 2009 | 2027 | |
| Pennsylvania | Robert P. Casey, Jr. (D) | 2007 | 2025 |
| Patrick J. Toomey (R) | 2011 | 2023 | |
| Rhode Island | Jack Reed (D) | 1997 | 2027 |
| Sheldon Whitehouse (D) | 2007 | 2025 | |
| South Carolina | Lindsey Graham (R) | 2003 | 2027 |
| Tim Scott (R) | 201317 | 2027 | |
| South Dakota | John Thune (R) | 2005 | 2023 |
| Mike Rounds (R) | 2015 | 2027 | |
| Tennessee | Marsha Blackburn (R) | 2019 | 2025 |
| Bill Hagerty (R) | 2021 | 2027 | |
| Texas | John Cornyn (R) | 2002 | 2027 |
| Ted Cruz (R) | 2013 | 2025 | |
| Utah | Mike Lee (R) | 2011 | 2023 |
| Mitt Romney (R) | 2019 | 2025 | |
| Vermont | Patrick J. Leahy (D) | 1975 | 2023 |
| Bernard Sanders (I) | 2007 | 2025 | |
| Virginia | Mark R. Warner (D) | 2009 | 2027 |
| Tim Kaine (D) | 2013 | 2025 | |
| Washington | Patty Murray (D) | 1993 | 2023 |
| Maria Cantwell (D) | 2001 | 2025 | |
| West Virginia | Joseph Manchin III (D) | 201018 | 2025 |
| Shelley Moore Capito (R) | 2015 | 2027 | |
| Wisconsin | Ron Johnson (R) | 2011 | 2023 |
| Tammy Baldwin (D) | 2013 | 2025 | |
| Wyoming | John Barrasso (R) | 200719 | 2025 |
| Cynthia M. Lummis (R) | 2021 | 2027 | |